Agenda

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Sunday Evening, April 11
6:30 - 8:30 pm	*Registration, Poster Setup* (City Center Ballroom) *Mixer* (Hors d’ouerves)

Monday, April 12
7:30 am	*Registration, Poster Setup, Continental Breakfast*
8:30 am	Introductions and Welcome (New Hampshire Ballroom) Chair: NF Metting
	Anna Palmisano, Associate Director, Office of Science, Biological and Environmental Research
	Sharlene Weatherwax, Division Director, Biological Systems Science Division
	Noelle Metting, Manager, Low Dose Radiation Research Program

Plenary Session I	Epigenetic Mechanisms and Radiation Exposure Chair: David Boothman, University of Texas, Southwestern
9:00 am	Olga Kovalchuk, University of Lethbridge Low Dose Radiation-Induced Epigenetic Changes in an Animal Model
9:15 am	Autumn Bernal, Duke University Imprinted Genes and Transposons: Epigenomic Targets for Low Dose Radiation Effects
9:30 am	Terumi Kohwi-Shigematsu, LBNL Genome-wide Changes in Epigenomics Induced by X-irradiation
9:45 am	Mary Helen Barcellos-Hoff, New York University Langone Medical Center Integrative Radiation Biology
10:00 am	*Coffee break*

Plenary Session II	Genetic Susceptibility and Modeling Chair: David Rocke, University of California - Davis
10:30 am	Allan Balmain, UC San Francisco Mouse genetic approaches to identification of radiation-induced tumor susceptibility genes
10:45 am	Brynn Voy, Oak Ridge National Laboratory Molecular Pathways That Mediate Genetic Susceptibility to Low Dose Ionizing Radiation
11:00 am	Philip Hahnfeldt, Tufts University Implications of Population Heterogeneity for Low-Dose Risk
11:15 am	Guest Speaker: Alice Sigurdson, NCI/Radiation Epidemiology Branch Radiation-related human cancer susceptibility: Progress and puzzles in the genome-wide studies era
12 - 1:30 pm	LUNCH (on your own)

Plenary Session III	Lawrence Berkeley National Laboratory Update Chair: Joe Gray
1:30 - 3:00 pm	LBNL Speakers TBD
3:00 pm	*Coffee Break*
3:30 pm	Monday Breakout Discussions: Radiation Effects on Cell-Cell Communication
	Discussion Group A (Potomac Room) Co-Chairs: Joel Bedford (Colorado State University) and Ellie Blakely (LBNL) P.I.s assigned; other Workshop participants may choose either group Discussions and summarization of main points
	Discussion Group B (Mt. Vernon Room) Co-Chairs: Ruth Globus (NASA-Ames) and Michael Weil (Colorado State University) P.I.s assigned; other Workshop participants may choose either group Discussions and summarization of main points
5:00 - 7:00 pm	Poster Session – City Center Ballroom (Hors d’ouerves)

Tuesday, April 13
7:30 am	*Registration, Poster Setup, Continental Breakfast*
Sister Low Dose Research Programs Chair: Noelle Metting, U.S. Department of Energy
8:30 am	European Research: MELODI/ DoReMi Guest Speaker: Sisko Salomaa, STUK, Finland
8:45 am	Low Dose Research in Japan Guest Speaker: Kazuo Sakai, National Institute of Radiological Sciences/Chiba
9:00 am	NASA Space Radiation Program Guest Speaker: Samuel Krenek, NASA-Johnson Space Center

Plenary Session IV	Radio-adaptive Responses and Modeling Chair: Peter O'Neill, Oxford University
9:15 am	Douglas Boreham, McMaster University The Mechanism of Low Dose Radiation Risk Associated With Diagnostic X-Rays and Gamma-Rays
9:30 am	Zhi-Min Yuan, University of Texas Health Science Center San Antonio The c-Abl Signaling Network in the Radio-Adaptive Response
9:45 am	Pamela Sykes, Flinders University Development of assays for Identification of mechanisms responsible for low dose radioprotective responses in vivo
10:00 am	Francis Cucinotta Mathematical Models of Signal Transduction in Adaptive Responses
10:15 am	*Coffee Break*

Plenary Session V	Radiation Biology - Levels of Complexity Chair: Janet Baulch, University of Maryland
10:45 am	Michael Cornforth, University of Texas Medical Branch Heritable Genetic Changes in Cells Recovered from Irradiated 3D Tissue Constructs
11:00 am	Munira Kadhim, Oxford Brookes University Mechanisms Underlying Cellular Responses to Low Dose/Low LET Ionizing Radiation in Primary Hemopoietic Cells
11:15 am	Norman Kleiman, Columbia University Radiation cataract as a model for low-dose ionizing radiation exposure and genetic determinants of radiosensitivity
11:30 am	Charles Limoli, University of California—Irvine Neurodegeneration in Response to Low-Dose Photon Irradiation: Strategies for Preserving Cognition
11:45 am	William Dynan, Medical College of Georgia Exploring links between persistent DNA damage, genome instability, and aging in the Japanese Medaka fish model
12:00 - 1:30 pm	LUNCH (on your own)
1:30 pm	Eric Hall, Columbia University Meeting Report: Low Dose Radiation Epidemiology—what have we learned?

Plenary Session VI	Travel Award Presentations Chair: Bill Morgan, PNNL
2:00 - 3:00 pm (1 hr)	Mahdokht Behravan, Tufts University Title TBD
	Manuela Buonanno, New Jersey Medical School Cancer Center Radiation quality and long-term biological effects in irradiated normal human cells and neighboring bystanders: The role of oxidative metabolism
	Ignacio Fernandez-Garcia, NYU Langone School of Medicine A link between stem cells and the EMT phenotype induced by IR and TGFβ
	Jody Filkowski, University of Lethbridge Title TBD
	Lahcen Jaafar, Medical College of Georgia Development of a 53BP1 transgenic Japanese medaka fish (Oryzias latipes) for investigation of long-term effects of low dose radiation exposure
	James Jacobus, University of Iowa LET is a critical factor in accelerating development of lymphoma in irradiated Bax transgenic C57/B6 mice
	Amit Mittal, Northwestern University The Effects of Radiation on Development of Prostate Cancer and Prostatic Hyperplasia in Canine Model
	Yuanlin Peng, Colorado State University Radiation Induced Chromatid-type Aberrations after Irradiation of Late-S/G2 Cells: Roles of Homologous Recombination and Non-Homologous End Joining
	Kristina Taylor, McMaster University Induction of DNA Damage by Low Dose PET scans
	Tyler Weeks, UC/Davis Development of Coherent Anti-Stokes Raman Scattering (CARS) Cytometry for Characterizing the Low-Dose Tissue Response
	Erik F Young, Columbia University Genetic Control of the Trigger for the G2/M Checkpoint
3:00 pm	*Coffee Break*
3:30 pm	Tuesday Breakout Discussions: Radio-Adaptive Responses
	Discussion Group A (Potomac Room) Co-Chairs: Sally Amundson (Columbia University) and Matt Coleman (LLNL) P.I.s assigned; other Workshop participants may choose either group Discussions with summarization of main points
	Discussion Group B (Mt. Vernon Room) Co-Chairs: Doug Spitz (Iowa State University) and Tony Brooks (WSU/PNNL) P.I.s assigned; other Workshop participants may choose either group Discussions with summarization of main points
5:00 - 7:00 pm	Poster Session – City Center Ballroom (Hors d’ouerves)

Wednesday, April 14
7:30 am	*Continental Breakfast*

Plenary Session VII	Low Dose Program Projects Chair: Daila Gridley, Loma Linda University
8:30 am	Lynn Hlatky, Tufts University Multi-Scale Systems Biology of Low-Dose Carcinogenesis Risk
9:00 am	Bobby Scott, Lovelace Radiation Research Institute Biological Bases for Radiation Adaptive Responses in the Lung
9:30 am	Gayle Woloschak, Northwestern University Effects of Low Dose Irradiation on NFkB Signaling Networks and Mitochondria
10:00 am	*Coffee Break*
10:30 AM	Breakout Discussion Reports
	Monday’s Topic – Radiation Effects on Cell-Cell Communication TBD (Drs Bedford, Blakely, Globus, Weil)
	Tuesday’s Topic – Radio-Adaptive Responses TBD (Drs Amundson, Jirtle, Spitz, Brooks)
~11:30 am	Meeting Adjourned

Agenda

Sunday Evening, April 11

Monday, April 12

Tuesday, April 13

Wednesday, April 14